We are always looking for highly-motivated individuals to join the LCPO! Interested undergraduate and graduate students can apply to the following offers. They are also strongly encouraged to contact LCPO's researchers directly.

Ring-Opening Polymerization Induced Self-Assembly of N-carboxyanhydrides

Ring-Opening Polymerization Induced Self-Assembly of N-carboxyanhydrides figure

Category: Ph. D.

Duration: 36 months

Team: Polymer self-assembly and life sciences

Funding: ANR

Laboratory: LCPO

Contacts : Colin Bonduelle

Applicant profile

We are looking for a motivated student with a solid background in organic or polymer chemistry. Skills in physical chemistry and nanomaterial characterization would be appreciated. If you are interested in this doctoral project, please contact Colin Bonduelle and apply to the dedicated CNRS application.

Project summary

Self-assembly of block polymers is a promising strategy to design advanced nanomaterials with unique properties. In this context, polymerization-induced self-assembly (PISA) is an emerging approach for accessing amphiphilic copolymers with the added benefit of simultaneously obtaining polymeric nanoparticles. Literature examples of PISA utilizing ring-opening polymerization are scarce while it would be a method of choice to prepare nanomaterials made of highly functional and biodegradable polymers. In this PhD project, we propose to develop the PISA preparation of polypeptide-based nanoparticles in aqueous solution using N-carboxyanhydride (NCA) monomers. Polypeptide polymers are already used in pharmaceutical applications with already marketed products and advanced clinical trials. This project will focus on amphiphilic polypeptide copolymers to be used in nanomedecine, a field of application in which they provide new solutions. This research project will allow the PhD student to acquire solid skills in the field of biodegradable polymers, copolymer synthesis, self-assembly and drug delivery.

The PhD project will be carried out at the LCPO which is a research laboratory in polymer sciences with a strong interest in several applications. The PhD candidate will work in the team “Polymer self-assembly and life sciences” under the supervision of Colin Bonduelle.

References: a) C. Bonduelle et al., Angew. Chem. Int. Ed. 2020, 59, 2, 622-626. b) C. Bonduelle et al., Nature Commun. 2020, 11, 2051. c) C. Bonduelle et al., J. Am. Chem. Soc. 2021, 3663-4082. d) https://inc.cnrs.fr/fr/cnrsinfo/une-synthese-et-un-auto-assemblage-verts-pour-les-polypeptides. e) https://inc.cnrs.fr/fr/cnrsinfo/des-polymeres-cycliques-contre-les-infections-clostridioides-difficile