Team 3 : Polymer self-assembly and life sciences

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The LCPO Team 3 is headed by Sébastien Lecommandoux and involves Colin Bonduelle, Elisabeth Garanger, Emmanuel Ibarboure, Angela Mutschler, Jean-François Le Meins, Olivier Sandre, and Christophe Schatz.

Nature uses everyday controlled and directed self-assembly processes involving molecular and macromolecular building blocks for the organization of complex structures that possess specific functions. Our aim is to mimic such self-assembly rules, especially by using synthetic bio-inspired amphiphilic copolymers based on synthetic polypeptides, bioengineered proteins, natural polysaccharides and their combinations.
We are especially interested in designing and synthesizing copolymers that can encode both self-assembly and bioactivity properties.
The understanding and characterization of multi-scale self-assembly of supramolecular structures that can interact with biological systems or mimic biological functions are of particular interest. We are especially fascinated by the design of smart amphiphilic copolymers, by the control of their self-assembly properties and by their use as drug delivery and theranostic systems, 3D-scafold, bioreactors or artificial cell mimics.

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Latest publications

Starch-fibers composites, a study of all-polysaccharide foams from microwave foaming to biodegradation Journal article

Quilez-Molina Ana Isabel, Le Meins Jean François, Charrier Bertrand, Dumon Michel

Journal title: Carbohydrate Polymers, Volume(s): 328, Page(s): 121743 https://hal.science/hal-04398152/document 10.1016/j.carbpol.2023.121743 (2024)

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New Insights on the Chemical Origin of Life: The Role of Aqueous Polymerization of N ‐carboxyanhydrides (NCA) Journal article

Moreno Abel, Bonduelle Colin

Journal title: ChemPlusChem 10.1002/cplu.202300492 (2024)

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Thermoresponsive polymers: From natural proteins to amino acid based polymer synthesis Journal article

Badreldin Mostafa, Salas-Ambrosio Pedro, Garanger Elisabeth, Lecommandoux Sébastien, Harrisson Simon, Bonduelle Colin

Journal title: Progress in Polymer Science, Volume(s): 147, Page(s): 101752 https://hal.science/hal-04272131/document 10.1016/j.progpolymsci.2023.101752 (2023)

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