Colin Bonduelle
Researcher
ANR JCJC - ROPISA
RING-OPENING POLYMERIZATION-INDUCED SELF-ASSEMBLY
Description : Polymerization-induced self-assembly (PISA) is a facile approach for accessing amphiphilic polymers with the benefit of obtaining at the same time polymeric nanoparticles at high concentration and in a scalable fashion. This project proposes the aqueous ring-opening polymerization (ROP) of hydrophobic N carboxyanhydrides (NCA) via their unprecedented reactivity in water using hydrophilic macroinitiator and via monomer protection from hydrolysis through spontaneous in situ self-assembly (ISA). This ROPISA process will afford well-defined amphiphilic diblock copolymers that simultaneously form nano-object having morphologies influenced by the secondary structure of the polypeptides, a unique feature of this PISA process
Funding : ANR-20-CE06-0020
