Research Key Areas :
Synthesis, characterization and application of protein-like polymers towards macromolecular therapeutics, nanomaterials/nanocomposites and bioactive scaffolds. More precisely, my research experience includes:
- Polymer synthesis by ring-opening polymerization/Organo-catalysis/Enzymatic catalysis.
- Synthesis and ring-opening reactivity of N-carboxyanhydrides/O-carboxyanhydrides/Lactones/Aqueous medium.
- Polymerization-induced/Cristallization-driven self-assembly and anisotropic nanomaterials.
- Alpha helical polymers, secondary structure, stimuli responsiveness (temperature, pH, etc.) and DNA recognition.
- Copolymers, macromolecular design, enzymatic degradation and antimicrobial properties.
- Nanoparticles in medical applications/Nanomedicine/Oral treatment.
- Molecular modelling through DFT calculations
Education and experience
I am biochemist by training and I did my PhD thesis in polymer chemistry to become an expert in ring-opening polymerization, a polymerization process that I have deeply studied experimentally (Chem. Commun. 2008, Biomacromolecules 2009, Chem. Eur. J. 2013) and by theoretical DFT methods (Chem. Eur. J. 2008). In order to combine this expertise with new skills in biomaterials development, I decided to move to Canada to join the Western University. As a postdoctoral associate in the Gillies lab, I developed unique elastomeric rubber with antifouling properties (2 patents WO, Macromolecules 2010, Macromolecules 2011, ACS AMI 2011). I also designed dendritic analogues of cell penetrating peptides and simple synthetic methods to graft them onto nanomaterials (Pharmaceuticals 2010, J. Polym. Sci. 2011, J. Matter Chem. 2012, Soft Mat. 2012). In a second postdoc position, I used all this experience to develop nanomaterials based on polypeptides (Polymer self-assembly group at LCPO/CNRS, JACS 2012, Chem. Commun. 2012). Combined to polysaccharides, I designed glycoprotein-like multivalency by polypeptide self-assembly (Farad. Disc. 2013, Chem. Commun. 2014, Chem. Commun. 2016).
I then joined in 2014 the “medicinal chemistry and biomimetic oxidations” group at LCC/CNRS, which specializes in bioinorganic chemistry and infectology. I developped new methodologies to synthesize N-carboxyanhydride (NCA) monomers and to perform their ring-opening polymerization. For instance, I developed unique polymers mimicking metalloproteins and nucleoproteins by using reversible interactions based on coordination chemistry or on DNA binding (Chem. Commun. 2017, Polym. Chem. 2017 and 2018, Biomacromolecules 2018). Such polypeptides are currently used to prepare new classes of bioinspired piezoelectric nanocomposites (Nat. Commun. 2020) or DNA-responsive nanomaterials (Polymers 2020, Biomacromolecules 2022).
After my Habilitation thesis (November 2018), I have decided to move back from Toulouse to Bordeaux to better develop breakthrough methodologies using ring-opening polymerization of N-carboxyanhydride at LCPO. Thanks to a unique collaboration with the Pasteur Institute, I have for instance achieved ring-expansion methodologies to mimick antimicrobial peptides (Biomacromolecules 2021, JACS 2021, Patent 2022 WO2022175319A1). Other main achievements include the development of aqueous ring-opening polymerization induced self-assembly processes (ROPISA, Angew. Chem. Int. Ed. 2020, VIP Paper, Patent 2021 WO2021/043865) or the use of aqueous ring-opening polymerization towards protein-like polymers with thermoresponsive properties (Angew. Chem. Int. Ed. 2022, Hot Paper).
Overall, my research developments have already resulted in patents and publications in major journals related to chemical sciences (JACS, Angewandte, Nature Communication...). My in-depth expertise in NCA chemistry as well as the new tools I developped recently in ring-opening polymerization is an excellent platform to conceive the polymers for tomorrow’s application following bioinspired and biomimectic polymer design.
Achievements and functions
2017 : Patent issued award, Vanguard Awards Winners, Worlddiscoveries, London, ON, Canada.
Since 2018 : member of the LIA "Laboratoire de Chimie Moleculaire avec Applications dans les Matériaux et la Catalyse" (France/Mexique)
2021 : CHP CNRS Promotion
Several works of Dr Colin Bonduelle were highlighted through press releases by the CNRS institute of chemistry (in French):
- Green synthesis and self-assembly for polypeptides
- A new concept for manufacturing hybrid nano-materials by self-assembly
- Cyclic peptoid polymers against Clostridium difficile infections
- Memory effect in thermoresponsive proline-based polymers
Representative seminar of Dr Colin Bonduelle research work (IIM Seminar, December 2022, UNAM Mexico) : Youtube link
Memory Effect in Thermoresponsive Proline‐based Polymers Journal article
Efficient Gene Delivery of Tailored Amphiphilic Polypeptides by Polyplex Surfing Journal article
Klemm Paul, Solomun Jana, Rodewald Marko, Kuchenbrod Maren, Hänsch Veit, Richter Friederike, Popp Jürgen, Hertweck Christian, Hoeppener Stephanie, Bonduelle Colin, Lecommandoux Sébastien, Traeger Anja, Schubert Stephanie