Team 3 : Polymer self-assembly and life sciences

Polymer self-assembly and life sciences logo

The LCPO Team 3 is headed by Sébastien Lecommandoux and involves Colin Bonduelle, Julien Es Sayed, Elisabeth Garanger, Chloé Grazon, Emmanuel Ibarboure, Paul Marque, and Angela Mutschler.


Nature uses everyday controlled and directed self-assembly processes involving molecular and macromolecular building blocks for the organization of complex structures that possess specific functions. Our aim is to mimic such self-assembly rules, especially by using synthetic bio-inspired amphiphilic copolymers based on synthetic polypeptides, bioengineered proteins, natural polysaccharides and their combinations.
We are especially interested in designing and synthesizing copolymers that can encode both self-assembly and bioactivity properties.
The understanding and characterization of multi-scale self-assembly of supramolecular structures that can interact with biological systems or mimic biological functions are of particular interest. We are especially fascinated by the design of smart amphiphilic copolymers, by the control of their self-assembly properties and by their use as drug delivery and theranostic systems, 3D-scafold, bioreactors or artificial cell mimics.

 

 

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Latest publications

  • A Minimal Hemin-Albumin Nanozyme with Peroxidase-like Activity Enabling Tyrosine-Crosslinked Hydrogel Formation figure

    A Minimal Hemin-Albumin Nanozyme with Peroxidase-like Activity Enabling Tyrosine-Crosslinked Hydrogel Formation Journal article

    López-Domene Rocío, Delhaes Alice, Lamouroux Arthur, Haykal Maria, Alembik Léna, Daubon Thomas, Martin Océane, Lecommandoux Sébastien, Garanger Elisabeth

    Journal title: ACS Applied Materials & Interfaces, Volume(s): 18, Issue(s): 35, Page(s): 47387-47401 https://hal.science/hal-05764606/document 10.1021/acsami.6c10477 (2026)

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  • Polymer-driven self-templated synthesis of boronate-COF hollow spheres: toward the development of size-selective nanoreactors figure

    Polymer-driven self-templated synthesis of boronate-COF hollow spheres: toward the development of size-selective nanoreactors Journal article

    Salaün Pauline, Mouloud Bahae-Eddine, Richard Élodie, Mariani Vincent, Tahon Jean-François, Addad Ahmed, Grazon Chloé, Woisel Patrice, Le Fer Gaëlle

    Journal title: ACS Applied Materials & Interfaces https://hal.science/hal-05727399/document 10.1021/acsami.6c06835 (2026)

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  • A Central Disulfide Junction Drives Transient Network Formation in Elastin-Like Polypeptides, Enabling Low-Concentration Hydrogels figure

    A Central Disulfide Junction Drives Transient Network Formation in Elastin-Like Polypeptides, Enabling Low-Concentration Hydrogels Journal article

    Zhang Tingting, Le Meins Jean-François, Chapel Jean-Paul, Catak Saron, Goudounet Guillaume, Sandre Olivier, Mahmoudi Nadia, Schatz Christophe, Garbay Bertrand

    Journal title: ACS Macro Letters, Volume(s): 15 https://u-bordeaux.hal.science/hal-05717870/document 10.1021/acsmacrolett.6c00338 (2026)

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