Team 3 : Polymer self-assembly and life sciences

Polymer self-assembly and life sciences logo

The LCPO Team 3 is headed by Sébastien Lecommandoux and involves Colin Bonduelle, Elisabeth Garanger, Chloé Grazon, Emmanuel Ibarboure, Paul Marque, and Angela Mutschler.


Nature uses everyday controlled and directed self-assembly processes involving molecular and macromolecular building blocks for the organization of complex structures that possess specific functions. Our aim is to mimic such self-assembly rules, especially by using synthetic bio-inspired amphiphilic copolymers based on synthetic polypeptides, bioengineered proteins, natural polysaccharides and their combinations.
We are especially interested in designing and synthesizing copolymers that can encode both self-assembly and bioactivity properties.
The understanding and characterization of multi-scale self-assembly of supramolecular structures that can interact with biological systems or mimic biological functions are of particular interest. We are especially fascinated by the design of smart amphiphilic copolymers, by the control of their self-assembly properties and by their use as drug delivery and theranostic systems, 3D-scafold, bioreactors or artificial cell mimics.

 

 

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Latest publications

  • Polymer-driven self-templated synthesis of boronate-COF hollow spheres: toward the development of size-selective nanoreactors figure

    Polymer-driven self-templated synthesis of boronate-COF hollow spheres: toward the development of size-selective nanoreactors Journal article

    Salaün Pauline, Mouloud Bahae-Eddine, Richard Élodie, Mariani Vincent, Tahon Jean-François, Addad Ahmed, Grazon Chloé, Woisel Patrice, Le Fer Gaëlle

    Journal title: ACS Applied Materials & Interfaces https://hal.science/hal-05727399/document 10.1021/acsami.6c06835 (2026)

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  • A Central Disulfide Junction Drives Transient Network Formation in Elastin-Like Polypeptides, Enabling Low-Concentration Hydrogels figure

    A Central Disulfide Junction Drives Transient Network Formation in Elastin-Like Polypeptides, Enabling Low-Concentration Hydrogels Journal article

    Zhang Tingting, Le Meins Jean-François, Chapel Jean-Paul, Catak Saron, Goudounet Guillaume, Sandre Olivier, Mahmoudi Nadia, Schatz Christophe, Garbay Bertrand

    Journal title: ACS Macro Letters, Volume(s): 15 https://u-bordeaux.hal.science/hal-05717870/document 10.1021/acsmacrolett.6c00338 (2026)

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  • Liquefied Multilayered Microcapsules Encapsulating Light-Responsive Polymersomes for On-Demand Temporally Controlled Enzyme-Mediated Cell Delivery figure

    Liquefied Multilayered Microcapsules Encapsulating Light-Responsive Polymersomes for On-Demand Temporally Controlled Enzyme-Mediated Cell Delivery Journal article

    Sousa Cristiana F V, Mutschler Angela, Ibarboure Emmanuel, Borges João, Lecommandoux Sébastien, Mano João F

    Journal title: Advanced Functional Materials, Volume(s): 36, Issue(s): 53, Page(s): e76473 https://hal.science/hal-05667876/document 10.1002/adfm.76473 (2026)

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