Team 3 : Polymer self-assembly and life sciences

Polymer self-assembly and life sciences logo

The LCPO Team 3 is headed by Sébastien Lecommandoux and involves Colin Bonduelle, Elisabeth Garanger, Emmanuel Ibarboure, Angela Mutschler, Jean-François Le Meins, Olivier Sandre, and Christophe Schatz.


Nature uses everyday controlled and directed self-assembly processes involving molecular and macromolecular building blocks for the organization of complex structures that possess specific functions. Our aim is to mimic such self-assembly rules, especially by using synthetic bio-inspired amphiphilic copolymers based on synthetic polypeptides, bioengineered proteins, natural polysaccharides and their combinations.
We are especially interested in designing and synthesizing copolymers that can encode both self-assembly and bioactivity properties.
The understanding and characterization of multi-scale self-assembly of supramolecular structures that can interact with biological systems or mimic biological functions are of particular interest. We are especially fascinated by the design of smart amphiphilic copolymers, by the control of their self-assembly properties and by their use as drug delivery and theranostic systems, 3D-scafold, bioreactors or artificial cell mimics.

 

 

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Latest publications

  • Influence of laboratory aging and asphaltene content of asphalt on frictional coefficient by tribological analysis − a case study figure

    Influence of laboratory aging and asphaltene content of asphalt on frictional coefficient by tribological analysis − a case study Journal article

    Verilhac Corentin, Barreto Gilles, Devès Lise, Delfosse Frédéric, Carlotti Stéphane, Lebarbé Thomas, Le-Meins Jean-François

    Journal title: Fuel, Volume(s): 379, Page(s): 133013 https://hal.science/hal-04836329/document 10.1016/j.fuel.2024.133013 (2025)

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  • Interactions between PEI and biological polyanions and the ability of glycosaminoglycans in destabilizing PEI/peGFP-C3 polyplexes for genetic material release figure

    Interactions between PEI and biological polyanions and the ability of glycosaminoglycans in destabilizing PEI/peGFP-C3 polyplexes for genetic material release Journal article

    Montaño González Paulina Alejandra, Montserrat Bravo-Lozano Lizeth, Chevance Soizic, Dole Francois, Rosselgong Julien, Loyer Pascal, Tranchimand Sylvain, Chapel Jean-Paul, Gauffre Fabienne, Schatz Christophe, Bravo-Anaya Lourdes Mónica

    Journal title: International Journal of Biological Macromolecules, Volume(s): 301, Page(s): 140351 https://hal.science/hal-04926834/document 10.1016/j.ijbiomac.2025.140351 (2025)

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