Team 3 : Polymer self-assembly and life sciences

Polymer self-assembly and life sciences logo

The LCPO Team 3 is headed by Sébastien Lecommandoux and involves Colin Bonduelle, Elisabeth Garanger, Emmanuel Ibarboure, Angela Mutschler, Jean-François Le Meins, Olivier Sandre, and Christophe Schatz.


Nature uses everyday controlled and directed self-assembly processes involving molecular and macromolecular building blocks for the organization of complex structures that possess specific functions. Our aim is to mimic such self-assembly rules, especially by using synthetic bio-inspired amphiphilic copolymers based on synthetic polypeptides, bioengineered proteins, natural polysaccharides and their combinations.
We are especially interested in designing and synthesizing copolymers that can encode both self-assembly and bioactivity properties.
The understanding and characterization of multi-scale self-assembly of supramolecular structures that can interact with biological systems or mimic biological functions are of particular interest. We are especially fascinated by the design of smart amphiphilic copolymers, by the control of their self-assembly properties and by their use as drug delivery and theranostic systems, 3D-scafold, bioreactors or artificial cell mimics.

 

 

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Latest publications

  • Advancing Artificial Cells with Functional Compartmentalized Polymeric Systems - In Honor of Wolfgang Meier figure

    Advancing Artificial Cells with Functional Compartmentalized Polymeric Systems - In Honor of Wolfgang Meier Journal article

    Palivan Cornelia G, Heuberger Lukas, Gaitzsch Jens, Voit Brigitte, Appelhans Dietmar, Borges Fernandes Barbara, Battaglia Giuseppe, Du Jianzhong, Abdelmohsen Loai, van Hest Jan C M, Hu Jinming, Liu Shiyong, Zhong Zhiyuan, Sun Huanli, Mutschler Angela, Lecommandoux Sebastien

    Journal title: Biomacromolecules, Volume(s): 25, Page(s): DOI: 10.1021/acs.biomac.4c00769 https://hal.science/hal-04684090/document 10.1021/acs.biomac.4c00769 (2024)

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  • Structure-Function Relationship of Iron Oxide Nanoflowers: Optimal Sizes for Magnetic Hyperthermia Depending on Alternating Magnetic Field Conditions figure

    Structure-Function Relationship of Iron Oxide Nanoflowers: Optimal Sizes for Magnetic Hyperthermia Depending on Alternating Magnetic Field Conditions Journal article

    Bejko Megi, Al Yaman Yasmina, Bagur Auriane, Keyes Jr Anthony C., Rosa Patrick, Gayot Marion, Weill François, Mornet Stéphane, Sandre Olivier

    Journal title: ChemPhysChem, Volume(s): 25, Issue(s): 18, Page(s): e202400023 https://hal.science/hal-04204571/document 10.1002/cphc.202400023 (2024)

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  • Tailoring the pore structure of iron oxide core@stellate mesoporous silica shell nanocomposites: effects on MRI and magnetic hyperthermia properties and applicability to anti-cancer therapies figure

    Tailoring the pore structure of iron oxide core@stellate mesoporous silica shell nanocomposites: effects on MRI and magnetic hyperthermia properties and applicability to anti-cancer therapies Journal article

    Bizeau Joëlle, Journaux-Duclos Justine, Kiefer Céline, Freis Barbara, Ihiawakrim Dris, Ramirez Maria de los Angeles, Lucante Theo, Parkhomenko Ksenia, Vichery Charlotte, Carrey Julian, Sandre Olivier, Bertagnolli Caroline, Ersen Ovidiu, Bégin-Colin Sylvie, Gigoux Véronique, Mertz Damien

    Journal title: Nanoscale, Volume(s): 16, Issue(s): 33, Page(s): 15585-15614 https://hal.science/hal-04673341/document 10.1039/d4nr01388c (2024)

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