Team 3 : Polymer self-assembly and life sciences

Polymer self-assembly and life sciences logo

The LCPO Team 3 is headed by Sébastien Lecommandoux and involves Colin Bonduelle, Elisabeth Garanger, Bertrand Garbay, Emmanuel Ibarboure, Angela Mutschler, Jean-François Le Meins, Olivier Sandre, Christophe Schatz and Amélie Vax-Weber.


Nature uses everyday controlled and directed self-assembly processes involving molecular and macromolecular building blocks for the organization of complex structures that possess specific functions. Our aim is to mimic such self-assembly rules, especially by using synthetic bio-inspired amphiphilic copolymers based on synthetic polypeptides, bioengineered proteins, natural polysaccharides and their combinations.
We are especially interested in designing and synthesizing copolymers that can encode both self-assembly and bioactivity properties.
The understanding and characterization of multi-scale self-assembly of supramolecular structures that can interact with biological systems or mimic biological functions are of particular interest. We are especially fascinated by the design of smart amphiphilic copolymers, by the control of their self-assembly properties and by their use as drug delivery and theranostic systems, 3D-scafold, bioreactors or artificial cell mimics.

Latest publications

  • Challenges and Recommendations for Magnetic Hyperthermia Characterization Measurements figure

    Challenges and Recommendations for Magnetic Hyperthermia Characterization Measurements Journal article

    Wells James, Ortega Daniel, Steinhoff Uwe, Dutz Silvio, Garaio Eneko, Sandre Olivier, Natividad Eva, Cruz Maria M, Brero Francesca, Southern Paul, Pankhurst Quentin A., Spassov Simo

    Journal title: International Journal of Hyperthermia, Volume(s): 38, Issue(s): 1, Page(s): 447-460 https://hal.archives-ouvertes.fr/hal-03161401/document 10.1080/02656736.2021.1892837 (2021)

  • Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization: Simple Access to Bioactive Backbones figure

    Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization: Simple Access to Bioactive Backbones Journal article

    Salas-Ambrosio Pedro, Tronnet Antoine, Since Marc, Bourgeade-Delmas Sandra, Stigliani Jean-Luc, Vax Amelie, Lecommandoux Sébastien, Dupuy Bruno, Verhaeghe Pierre, Bonduelle Colin

    Journal title: Journal of the American Chemical Society, Volume(s): 143, Issue(s): 10, Page(s): 3697-3702 https://hal.archives-ouvertes.fr/hal-03173586/document 10.1021/jacs.0c13231 (2021)