Team 3 : Polymer self-assembly and life sciences

Polymer self-assembly and life sciences logo

The LCPO Team 3 is headed by Sébastien Lecommandoux and involves Colin Bonduelle, Elisabeth Garanger, Emmanuel Ibarboure, Angela Mutschler, Jean-François Le Meins, Olivier Sandre, and Christophe Schatz.


Nature uses everyday controlled and directed self-assembly processes involving molecular and macromolecular building blocks for the organization of complex structures that possess specific functions. Our aim is to mimic such self-assembly rules, especially by using synthetic bio-inspired amphiphilic copolymers based on synthetic polypeptides, bioengineered proteins, natural polysaccharides and their combinations.
We are especially interested in designing and synthesizing copolymers that can encode both self-assembly and bioactivity properties.
The understanding and characterization of multi-scale self-assembly of supramolecular structures that can interact with biological systems or mimic biological functions are of particular interest. We are especially fascinated by the design of smart amphiphilic copolymers, by the control of their self-assembly properties and by their use as drug delivery and theranostic systems, 3D-scafold, bioreactors or artificial cell mimics.

 

 

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Latest publications

  • Biomimetic metal-phenolic network-coated elastin-like polypeptide micelles as an immunogenic cell death inducer for orthotopic glioma sonodynamic-chemodynamic-immune therapy figure

    Biomimetic metal-phenolic network-coated elastin-like polypeptide micelles as an immunogenic cell death inducer for orthotopic glioma sonodynamic-chemodynamic-immune therapy Journal article

    Wang Zhiqiang, Guo Yunqi, Li Gaoming, Guo Honghua, Li Yanying, Wang Jinxia, Li Kangan, Mignani Serge, Shen Mingwu, Garanger Elisabeth, Lecommandoux Sébastien, Shi Xiangyang

    Journal title: Nano Today, Volume(s): 64, Page(s): 102810 10.1016/j.nantod.2025.102810 (2025)

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  • Production of recombinant methionine‐containing elastin‐like polypeptides in a fermenter using ECPM1 medium figure

    Production of recombinant methionine‐containing elastin‐like polypeptides in a fermenter using ECPM1 medium Journal article

    Delhaes Alice, Bataille Laure, Médéric Myriam, Lecommandoux Sébastien, Garanger Elisabeth

    Journal title: Biotechnology Progress 10.1002/btpr.70057 (2025)

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  • Merging Natural Biopolymers with Supramolecular Chemistry: Emulating the Native Extracellular Matrix’s Complexity figure

    Merging Natural Biopolymers with Supramolecular Chemistry: Emulating the Native Extracellular Matrix’s Complexity Journal article

    Sousa Vera, Ladeira Bruno, Garanger Elisabeth, Lecommandoux Sébastien, Meijer E., Dankers Patricia, Mano João, Borges João

    Journal title: ACS Nano, Volume(s): 19, Issue(s): 33, Page(s): 29833-29859 10.1021/acsnano.5c10088 (2025)

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