Team 3 : Polymer self-assembly and life sciences

Polymer self-assembly and life sciences logo

The LCPO Team 3 is headed by Sébastien Lecommandoux and involves Colin Bonduelle, Elisabeth Garanger, Bertrand Garbay, Emmanuel Ibarboure, Angela Mutschler, Jean-François Le Meins, Olivier Sandre, Christophe Schatz and Amélie Vax-Weber.


Nature uses everyday controlled and directed self-assembly processes involving molecular and macromolecular building blocks for the organization of complex structures that possess specific functions. Our aim is to mimic such self-assembly rules, especially by using synthetic bio-inspired amphiphilic copolymers based on synthetic polypeptides, bioengineered proteins, natural polysaccharides and their combinations.
We are especially interested in designing and synthesizing copolymers that can encode both self-assembly and bioactivity properties.
The understanding and characterization of multi-scale self-assembly of supramolecular structures that can interact with biological systems or mimic biological functions are of particular interest. We are especially fascinated by the design of smart amphiphilic copolymers, by the control of their self-assembly properties and by their use as drug delivery and theranostic systems, 3D-scafold, bioreactors or artificial cell mimics.

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Latest publications

  • Control of Enzyme Reactivity in Response to Osmotic Pressure Modulation Mimicking Dynamic Assembly of Intracellular Organelles. figure

    Control of Enzyme Reactivity in Response to Osmotic Pressure Modulation Mimicking Dynamic Assembly of Intracellular Organelles. Journal article

    Schvartzman Clémence, Zhao Hang, Ibarboure Emmanuel, Ibrahimova Vusala, Garanger Elisabeth, Lecommandoux Sébastien

    Journal title: Advanced Materials, Volume(s): 35, Page(s): e2301856 https://hal.science/hal-04109203/document 10.1002/adma.202301856 (2023)

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  • Origin, exposure routes and xenobiotics impart nanoplastics with toxicity on freshwater bivalves figure

    Origin, exposure routes and xenobiotics impart nanoplastics with toxicity on freshwater bivalves Journal article

    Arini Adeline, Muller Sandra, Coma Véronique, Grau Etienne, Sandre Olivier, Baudrimont Magalie

    Journal title: Environmental science‎.Nano, Volume(s): 10, Issue(s): 3, Page(s): doi: 10.1039/D3EN00022B https://hal.science/hal-03834325/document 10.1039/D3EN00022B (2023)

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  • Deep Chemical and Physico-Chemical Characterization of Antifungal Industrial Chitosans—Biocontrol Applications figure

    Deep Chemical and Physico-Chemical Characterization of Antifungal Industrial Chitosans—Biocontrol Applications Journal article

    Huet Gaël, Wang Yunhui, Gardrat Christian, Brulé Daphnée, Vax Amélie, Le Coz Cédric, Pichavant Frédérique, Bonnet Silvère, Poinssot Benoit, Coma Véronique

    Journal title: Molecules, Volume(s): 28, Issue(s): 3, Page(s): 966 https://hal.science/hal-03976563/document 10.3390/molecules28030966 (2023)

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