Team 3 : Polymer self-assembly and life sciences

Polymer self-assembly and life sciences logo

The LCPO Team 3 is headed by Sébastien Lecommandoux and involves Colin Bonduelle, Elisabeth Garanger, Bertrand Garbay, Emmanuel Ibarboure, Angela Mutschler, Jean-François Le Meins, Olivier Sandre, Christophe Schatz and Amélie Vax-Weber.


Nature uses everyday controlled and directed self-assembly processes involving molecular and macromolecular building blocks for the organization of complex structures that possess specific functions. Our aim is to mimic such self-assembly rules, especially by using synthetic bio-inspired amphiphilic copolymers based on synthetic polypeptides, bioengineered proteins, natural polysaccharides and their combinations.
We are especially interested in designing and synthesizing copolymers that can encode both self-assembly and bioactivity properties.
The understanding and characterization of multi-scale self-assembly of supramolecular structures that can interact with biological systems or mimic biological functions are of particular interest. We are especially fascinated by the design of smart amphiphilic copolymers, by the control of their self-assembly properties and by their use as drug delivery and theranostic systems, 3D-scafold, bioreactors or artificial cell mimics.

Latest publications

  • Surface Immobilized Nucleic Acid–Transcription Factor Quantum Dots for Biosensing figure

    Surface Immobilized Nucleic Acid–Transcription Factor Quantum Dots for Biosensing Journal article

    Chen Mingfu, Nguyen Thuy, Varongchayakul Nitinun, Grazon Chloé, Chern Margaret, Baer R., Lecommandoux Sébastien, Klapperich Catherine, Galagan James, Dennis Allison, Grinstaff Mark

    Journal title: Advanced Healthcare Materials, Volume(s): 9, Issue(s): 17, Page(s): 2000403 https://hal.archives-ouvertes.fr/hal-02904157/document 10.1002/adhm.202000403 (2020)

  • Hydrogel embedded quantum dot-transcription factor sensor for quantitative progesterone detection figure

    Hydrogel embedded quantum dot-transcription factor sensor for quantitative progesterone detection Journal article

    Chen Mingfu, Grazon Chloé, Sensharma Prerana, Nguyen Thuy, Feng Yunpeng, Chern Margaret, Baer R., Varongchayakul Nitinun, Cook Katherine, Lecommandoux Sebastien, Klapperich Catherine, Galagan James, Dennis Allison, Grinstaff Mark

    Journal title: ACS Applied Materials & Interfaces, Volume(s): 12, Page(s): doi 10.1021/acsami.0c13489 https://hal.archives-ouvertes.fr/hal-02939691/document 10.1021/acsami.0c13489 (2020)

  • Self-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly figure

    Self-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly Journal article

    Dao Tuyen, Vezenkov Lubomir, Subra Gilles, Amblard Muriel, In Martin, Le Meins Jean-François, Aubrit Florian, Moradi Mohammad-Amin, Ladmiral Vincent, Semsarilar Mona

    Journal title: Macromolecules, Volume(s): 53, Issue(s): 16, Page(s): 7034-7043 10.1021/acs.macromol.0c01260 (2020)