Team 3 : Polymer self-assembly and life sciences

Polymer self-assembly and life sciences logo

The LCPO Team 3 is headed by Sébastien Lecommandoux and involves Colin Bonduelle, Elisabeth Garanger, Emmanuel Ibarboure, and Angela Mutschler.


Nature uses everyday controlled and directed self-assembly processes involving molecular and macromolecular building blocks for the organization of complex structures that possess specific functions. Our aim is to mimic such self-assembly rules, especially by using synthetic bio-inspired amphiphilic copolymers based on synthetic polypeptides, bioengineered proteins, natural polysaccharides and their combinations.
We are especially interested in designing and synthesizing copolymers that can encode both self-assembly and bioactivity properties.
The understanding and characterization of multi-scale self-assembly of supramolecular structures that can interact with biological systems or mimic biological functions are of particular interest. We are especially fascinated by the design of smart amphiphilic copolymers, by the control of their self-assembly properties and by their use as drug delivery and theranostic systems, 3D-scafold, bioreactors or artificial cell mimics.

 

 

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Latest publications

  • Beta-Glucan Nanogels Mediate Intracellular Delivery of Elastin-Like Polypeptides for Efficient Macrophage Polarization figure

    Beta-Glucan Nanogels Mediate Intracellular Delivery of Elastin-Like Polypeptides for Efficient Macrophage Polarization Journal article

    Zhang Ziwen, Wang Jinxia, Zhao Qi, Chen Ting, Shen Mingwu, Mignani Serge, Garanger Elisabeth, Lecommandoux Sébastien, Shi Xiangyang

    Journal title: Biomacromolecules 10.1021/acs.biomac.6c00017 (2026)

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  • Wireless Electromechanical Fluorophore Release From Soft Polymer Actuators figure

    Wireless Electromechanical Fluorophore Release From Soft Polymer Actuators Journal article

    Vinod Anaga, Goudeau Bertrand, Daniel Jonathan, Grazon Chloé, Kuhn Alexander, Salinas Gerardo

    Journal title: Macromolecular Materials and Engineering, Volume(s): 311, Issue(s): 3, Page(s): e00472 https://hal.science/hal-05609381/document 10.1002/mame.202500472 (2026)

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  • Low-cost highlighter nanoparticles for highly efficient multistep excitation energy transfer figure

    Low-cost highlighter nanoparticles for highly efficient multistep excitation energy transfer Journal article

    Piard Jonathan, Degano Ilaria, Doré Clément, Audibert Jean-Frédéric, Grazon Chloé, Allain Clémence, Bertrand Loïc

    Journal title: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy [1994-...], Volume(s): 352, Page(s): 127477 https://hal.science/hal-05537216/document 10.1016/j.saa.2026.127477 (2026)

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