NATPRIME

NATPRIME - Effective Delivery of Nucleic Acid Therapeutics via Designed Nanocarriers

NATPRIME is a European project funded by the European Union’s Horizon Europe research and innovation programme under the Marie Skłodowska-Curie grant agreement n° 101168881. Twenty collaborative projects have been designed between the academic and industrial scientists of NATPRIME. Each of these projects aims to solve a critical problem to advance the use of nanoparticles for the delivery of nucleic acid therapeutics. We believe these small steps in scientific development will create the next generation of biomedical treatment methods.

At the LCPO, two research projects are carried out within NATPRIME in the team “Polymer self-assembly and life sciences” led by Prof. Sébastien Lecommandoux.

The first project focuses on the design of polyion complex vesicles (PICsomes) from polypeptide-based block copolymers. Using PEG and polysaccharide-derived macroinitiators, the objective is to develop new nanocarriers for nucleic acid delivery and investigate their formulation and biophysical properties. This work involves international collaborations with the University of Warwick and the Technical University of Eindhoven .

The second project aims to develop chemotaxis-driven delivery systems using asymmetric polymersomes (Janus vesicles). Amphiphilic copolymers are synthesized to enable phase separation and asymmetric functionalization. By decorating the surface with enzymes and targeting peptides, the goal is to engineer nanosystems capable of directional motion and targeted delivery, from in vitro to in vivo studies. This project includes secondments at the University of Warwick and the University of Strathclyde.

Website : https://www.natprime.org/