Flow Chemistry Platform - Amethyst

AMETHYST logo

AMETHYST is an automated flow chemistry platform at the LCPO dedicated to accelerating polymer development through continuous synthesis, real-time analysis, and machine learning. By combining modular flow reactors with data-driven optimization, the platform rapidly explores reaction conditions and identifies optimal pathways to targeted polymer properties. Designed for both fundamental and applied research, AMETHYST supports the development of sustainable polymers and fosters collaborations with academic and industrial partners.

Contact Simon Harrisson for more information.

 

  • Kia sets up an experiment
  • Glenn runs an NMR
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Selected Publications

Closed-loop Bayesian optimization in flow enables rapid identification of optimal conditions for organocatalyzed ring-opening polymerization of δ-valerolactone.

Taming the tiger: Bayesian optimization of organocatalyzed ring-opening polymerization in flow

Glenn K. K. Clothier, Olivier Doat, Bo Li, Daniel Taton, Simon Harrisson

Polym. Chem. 2026, 17, 3275-3286

Graphic. Refer to the image caption for details.

Exploiting Machine Learning and Automated Synthesis in Continuous Flow for Process Optimization of the Organocatalyzed Ring-Opening Polymerization of l‑Lactide

Glenn K. K. Clothier, Daniel Taton, Simon Harrisson

ACS Polym. Au, 2025, 5, 603-612

Reanalysis of flow polymerization kinetics of TBD-catalyzed l-lactide polymerization using an initial-rate approach reveals deviations from first-order behavior and supports a revised rate law.

Comment on “Multidimensional kinetic study on the organocatalyzed ring-opening polymerization (ROP) of l-lactide via a robotic high-throughput flow platform” by B. Zhang and T. Junkers, Chem. Sci., 2026, 17, 4706

Glenn K. K. Clothier, Simon Harrisson

Chem. Sci., 2026, 17, 12142-12146